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CERo Therapeutics, Inc. Presents Encouraging Preclinical Data for AML on CER-1236 at Stanford Drug Discovery Symposium Highlighting Tumor Elimination and Manufacturing Attributes

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CERo Nov 2022

CER T Cells with a TLR2 Domain Synergize with an EGFR Inhibitor to Target NSCLC Cells In Vitro and Demonstrate APC-like Function

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ASGCT May 2022

CER T Cells Synergize with PARPi to Kill Ovarian Tumor Cells

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SITC November 2021

CERo Therapeutics’ Novel Chimeric Engulfment Receptor T Cells Exhibit Multifunctional Properties and Enhanced Tumor Killing

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Cieniewicz B, Bhatta, A, Torabi, D, Corey, D. Chimeric TIM-4 receptor-modified T cells targeting phosphatidylserine mediates both cytotoxic anti-tumor responses and phagocytic uptake of tumor-associated antigen for T cell cross presentation. Molecular Therapy. 2023.

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Ravichandran KS. Find-me and eat-me signals in apoptotic cell clearance: progress and conundrums.
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Norimoto Kobayashi1, Piia Karisola, Victor Peña-Cruz, David M Dorfman, Masahisa Jinushi, Sarah E Umetsu, Manish J Butte, Haruo Nagumo, Irene Chernova, Baogong Zhu, Arlene H Sharpe, Susumu Ito, Glenn Dranoff, Gerardo G Kaplan, Jose M Casasnovas, Dale T Umetsu, Rosemarie H Dekruyff, Gordon J Freeman TIM-1 and TIM-4 glycoproteins bind phosphatidylserine and mediate uptake of apoptotic cells. Immunity 2007 Dec;27(6):927-40.

Phosphatidylserine biology and targeting

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Budhu S, Giese R, Gupta A, Fitzgerald K, Zappasodi R, Schad S, Hirschhorn D, Campesato LF, De Henau O, Gigoux M, Liu C, Mazo G, Deng L, Barker CA, Wolchok JD, and Merghoub T. Targeting phosphatidylserine enhances the anti-tumor response to tumor-directed radiation therapy in pre-clinical model of melanoma. Cell Rep 2021; 34(2): 108620.

Schad S, Hirschhorn-Cymerman D, Budhu S, Zhong H, Yang X, Merghoub T, and Wolchok JD. Phosphatidylserine targeting antibody enhances anti-tumor activity of adoptive cell therapies in a mouse melanoma model. J Immunol 2020, 204 (1 Supplement) 170.5.

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Professional antigen presentation by activated T cells

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Role of tumor in microenvironment

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Chen, Pei Hsuan. JCI Insight. 2020;5(12) Activation of CAR and non-CAR T cells in the tumor micro environment following CAR T cell therapy